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Cysteine, which is essential for glutathione synthesis, is acquired primarily in its oxidized form, cystine, via the cystine/glutamate antiporter (system x c , comprising the subunits SLC7A11 and SLC3A2), or it is synthesized from methionine and glucose through the trans-sulfidation pathway

Our results reveal early metabolomic dysfunction in the motor cortex of prpTDP-43 A315T mice and begin to suggest that reestablishing the perturbed balance may help UMNs regain their health and stability

Cryopreservation maintains functionality of human iPSC dopamine neurons and rescues parkinsonian phenotypes in vivo

Manini I, Caponnetto F, Bartolini A, Ius T, Mariuzzi L, Di Loreto C, et al

doi: 10.1016/j.neurobiolaging.2014.07.041

Oxidative stress regulates mitogen-activated protein kinases and c-Jun activation involved in heat stress and lipopolysaccharide-induced intestinal epithelial cell apoptosis